Morphohystochemistry of the placentas at HIV-infection with drug addiction has been studied. Plural hemodinamic, involutive, distrophical and not so much expressed compensatory, adaptive processes, malfunctions of placental metabolism, which has led to development of recurrent chronic, relative deficiency of placenta in all cases. Mentioned pathological processes were combined with inflamatory injures of placenta’s tissues, which had a negative influence on the fetal condition.