THE COMPARATIVE HEPATOPROTECTIVE, ANTIDYSBIOTIC AND HYPOLIPIDEMIA EFFECTS OF FLAVANS MEANS WITH AT EXPERIMENTAL TOXIC HEPATITIS

Aim: To investigate hepatoprotectors activity of two new antidysbiotic means lequin and lekasil at toxic hepatitis.

Materials and methods. The hepatitis was reproduced by introduction of hydrazine sulfate on 8th, 9-th and 10-th days of the experiment. The 3 means were used at 1st day of the experiment in dose 300 mg/kg during 14 days. Quertulyn (quercetin + inulin + Ca citrate), lequin (lecithin + quertulyn) and lecasil (lecithin + oil cake of Silybum maranum + citrate Ca) were used. The liver markers (bilirubin, ALT, alkaline phosphatase) and activity of urease and lysozyme were determined in serum. The level of triglyceride and cholesterin were determined in the liver and serum.

Results: All three preparations lower the levels of liver markers, so rendering heparoprotective action and degree of dysbiosis, lecasil to greater extent. Level of triglycerides and cholesterine in the liver and blood serum were lowered by lecasil to greater extent.

Conclusion: The new antidysbiotic means lequin and lecasil have hepatoprotective action better than quertulyn.