Over the past 10 years in Ukraine has doubled the number of patients with chronic brain ischemia, one of the main manifestations of which are cognitive impairment and depressive symptoms. Only a few reports of the use of transcranial magnetic stimulation for patients with chronic cerebral ischemia induced us to the justification of biophysical parameters of this method in this pathology.
We examined 27 male and 35 female, age 46–72 years. 32 patients underwent 10 sessions of 10 minutes of low-intensity high-frequency (0.3 T, 20 Hz) stimulation of the dorsolateral prefrontal cortex on the left, 30 patients received a similar course of high-intensity low-frequency (1.6 T, 1 Hz) stimulation. Patients were determined before and after the course with the MMSE test and Hamilton scale. Cognitive condition in the first group improved in 43.8% of patients (c2 McNemar 11,13; p=0,00085), while the second group in 26.7% (c2 McNemar 15.04; p=0.0001), the depressed condition manifestations in the first group improved in 18.8% patients (c2 McNemar 12.25; p=0.0005), and the second group in 6.7% (c2 McNemar 0.893; p=0.345), which made it possible to conclude that when using this mode of action depressive symptoms are reduced, but not statistically significant. Thus, the optimal biophysical parameters of the positive impact on the state of cognitive function and depressive symptoms are: stimulation of the left dorsolateral prefrontal cortex with the intensity of the magnetic field — 0.3 T, frequency — 20 Hz, session time — 10 minutes, the duration of the course — 10 daily sessions.