The inflammation is a protective reaction of the organism to the damaging agent. The ibuprofen has anti-inflammatory, antipyretic and anti-edema effect. But ibuprofen has side effects also.
Purpose: The biochemical response of the organism has been studied in the process of experimental inflammation by carrageenan. Esters of ibuprofen were delivered through the skin by ointment.
The inflammation was induced by subplantar injection of 0.2 ml of 0.2% carrageenan solution into the right (rear) limbs of rats. Esters were synthesized from the aliphatic alcohols and ibuprofen. For these reactions were used methyl, ethyl, octyl and hexadecyl alcohols.
The blood was collected every second day, starting from the first day of the experiment, during the 10 days of the experiment. The treatment was performed by transdermal administered of the referent drug — ibuprofen, and its esters.
Biochemical parameters were determined, based on the dynamics of the cholinesterase activity, total protein, seromucoids and sialic acids in the blood plasma of experimental rats.
In the group where we used ibuprofen, cholinesterase activity decreased slowly, but was increased on the fourth day. In the experimental groups where used esters, the cholinesterase activity in rat plasma was restored on the second day of the experiment.
Esters of ibuprofen have a high anti-inflammatory activity, after transdermal delivery. They have a positive effect on the biochemical reaction in rats during inflammation. They reduce the level of imbalance and accelerate the return to the concentration of biochemical indicators seromucoids, sialic acids and total protein.