The aim of the investigation was to determine the clinical manifestations, electrophysiological parameters and thermal imaging references in 58 patients with polyneuropathy after some intoxications: alcoholic, toxicomaniac and poisoning of heavy metals. We investigated motor and sensor fiber of the ulnar, median, peroneal and tibial nerves on a distal segments of the extremities at the level of forearm and leg, respectively, and carry out the needle electromyography and clinical examination. In about 60 % of patients it was defined axonal defeat of the peripheral nerves with the reduction of motor conduction velocities, about 40 % — mixed forms (axonomyelopathies) with the reduction of the amplitude of M-wave and MCV.