SPECIFICS OF T-CELL IMMUNITY IN ISOANTIGEN INCOMPABILITY IN PREGNANT WOMEN

In pregnant women with isoantigen incompatibility takes place sensitization of cytotoxic T-lymphocytes to histocompatibility antigens inherited from father. As a result the total number of T-lymphocytes and immunoregulatory index value increase.

Aim. evaluation of T-cell immunity in isoantigen incompatibility during pregnancy.

Materials and Methods. The study involved 37 pregnant women with Rh-conflict (study group) and 30 women with physiological pregnancy (control group) in term of 28–32 weeks of gestation. Comprehensive assessment of the immunological profile was performed by flow cytometry with immunoregulatory index computation.

Results. In most cases izoantigen conflict was latent, which manifested itself in the form of increase titer of Rh-antibodies. In some pregnant women (n=12; 32.4%) manifestations of hemolytic disease of fetus were identified by ultrasonography as mild hepatomegaly. In the control group pregnancies were uncomplicated. We found that pregnant women with izoantigen incompatibility had reduced number of CD3+CD8+ cells accompanied with increase in immunoregulatory index upto 2.6±0.1 (in control group — 2.2±0.1).

Conclusion. In pregnant women with izoantigen incompatibility reduced number of CD3+ CD8+ cells is accompanied with increased immunoregulatory index up to 2.6±0.1. There was determined a strong inverse correlation (r=-0.83 p<0.05) between the content of activated T-suppressor immunoregulatory index and value. Described changes indicate activation of immune system in women with Rh-conflict that can lead to miscarriage or fetal loss.