Influence of hypoxic-hypercapnia stimulus and non-invasive magneto-laserotherapy combined application in patients suffering from COPD on the stage of sanitary-resort treatment has been studied. It is set that use of such combination in patients with COPD allows to obtain expressed local and moderate systemic anti-inflammatory effect; to improve external breathing function and cardiovascular system condition; to increase patients’ motor activing and arterial blood oxygen saturation; to improve the state of immune system.