In experiments on Wistar’s male rats distinctions in nootrops’ action on the right and left cerebral hemispheres are studied by conducting of neuromorphological research with the use of immunohistochemical methods. The model of experimental ischemic stroke was used. Pathology was designed by bilateral ligation of the general carotids at rats. Some distinctions are set in nootrops influence on renewal of right and left hemispheric nervous tissue. A tendency to the pyracetame righthemispheric action and righthemispheric lateralization of phenibute neuroprotective action in the condition of experimental brain pathology was found.