STATE OF ANTIOXIDATIVE PROTECTIVE SYSTEM DURING GALACTOSAMINE-INDUCED HEPATITIS AND USING OF DERIVATIVE OF OXYETHYLYDENDIPHOSPHONATOGERMANATES (Report 2)

Information on the influence of new BAS of oxyethylydendiphosphonate germanate (MIGU-4, MIGU-5 and MIGU-6) on nonenzymatic part of the cellular antioxidant system at galactozamine hepatitis at rats is given. Researches showed that at preventive-cure course administration all studied compounds substantially prevented decreasing of a natural antioxidant like tocoferol in the membranes of erythrocytes and in the liver of animals, diminished peroxidative resistance of the erythrocytes and total peroxidative activity of the serum. According to force and expression of the pharmacological influence they are disposed in the following order: MIGU-4 > MIGU-5 > > MIGU-6 > heptral.