AGE AND SEX-RELATED STRUCTURAL AND FUNCTIONAL CHANGES OF BONE REMODELING IN LVIV REGION RESIDENTS

Introduction. Bone tissue is metabolically active system. However, recent studies have shown that calcium, iodine, zinc and fluorine deficiency, sedentary lifestyle, bad habits lead to violation of bone mineralization in childhood and adolescence.

Aim. To study the structural and functional state of cortical and trabecular layers of lumbar vertebrae L1–L5 in different age groups living in the Lviv region.

Materials and methods. In order to assess bone mineral density of the lumbar vertebrae there were examined 144 people aged 5 to 85 year. Study of bone mineral density cortical and trabecular layer of lumbar vertebrae (L1–L5) was performed by computed tomography in Haunsfild Units (HU) in terms of standard deviation (SD).

Results. The results of computed tomography showed a direct relationship of bone mineral density of cortical and trabecular layers of lumbar vertebrae with age of examined persons. Osteoporosis and osteopenic syndrome was registered in 15% of men and 30% women in first middle age, in second age of maturity 35% and 50% respectively. With the onset of elderly osteopenic syndrome and osteoporosis accounted 37.5% and 25% of men and 26% and 64% of women. Osteoporosis in old age was recorded in 50% of men and 75% women.

Conclusions. Results of the study showed a direct link between mineral density, age and gender. Mineral actively increasing bone mass starting with children to mature first, followed by mineral supply stabilizes. Then it is observed loss of bone mass throughout life.