In experiments on not pedigree white rats we studied the features of tramadol interaction with nonsteroid antiinflammatory drugs. Highly-pronounced potentiation effects are revealed in unselective blockers COG-1 diclofenac and ketoprofen and selective blocker COG-2 rofecoxib. At the study of effects of combinations it was established the activation of both suprasegmental and segmental mechanisms of adjusting analgesia.
