Choice of combined therapy for treatment of arterial hypertension (AH) associated with coronary artery disease (CAD) is not easy because of pharmacotherapy (PT) peculiarities in the elder age. Low efficacy of PT requires new informative methods for evaluation of homeostatic alterations and assessment of influence of treatment on metabolic processes. The object of our investigation was to reveal efficacy and safety of two antihypertensive combinations during their influence on hemodynamic, metabolic and subfractional status in elderly patients with PH II, III stage combined with CAD. For this purpose 80 patients were examined and treated according to medical standarts in the University Clinic of the Odessa National Medical University. Their mean age was (65.8±8.5) years. The patients were divided into 2 groups according to pathology: patients with AH II + CAD and AH III + CAD. The first antihypertensive combination “lisinopril, bisoprolol, cardiomagnil” was prescribed to the patients with AH II + CAD (group I) and with AH III + CAD (group II). The second antihypertensive combination “lisinopril, bisoprolol, indapamide, cardiomagnil” was prescribed in the patients with AH II + CAD (group III) and with AH III + CAD (group IV). N=20 in each group. Special investigation method was laser correlation spectrometry (LCS). Both combinations caused hemodynamic parameters normalization. In the group AH II + CAD they led to improvement of blood coagulation capacity, decrease of total cholesterol level and didn’t influence on kidney function. But in the group AH III + CHD these combinations caused functional renal insufficiency: increase of creatinine level and decrease of glomerular filtration rate. So, they are not pharmacologically safe for this group. In this case we should correct dosage regimen, follow up kidney function and cancel PT in the case of acute renal failure. LCS is sensitive method in detecting of side effects of the drugs, confirming cholesterol level decrease and allows to distinguish between different stages of AH both before and after PT.