Aim — a comparative evaluation of apelin-12 metabolism in patients with concomitant gastroesophageal reflux disease (GERD) and arterial hypertension (AH) and isolated AH.
Methods and results. The study included 95 patients with isolated AH 2 stage 1–3 degrees and 126 patients with GERD and AH 2 stage 1–3 degrees. Ambulatory blood pressure monitoring, determination of serum SH-groups, nitrite and nitrate, apelin-12 in plasma was performed according to standard procedures. The level of apelin-12 in patients with concomitant GERD and AH (755.15± ±15.46 pg/ml) was significantly higher than in patients with isolated AH (674.21±17.07 pg/ml) had a negative correlation (r=-0.23, p<0.01) with age, and in males level of apelin was significantly higher (p<0.01) than that in female. In patients with isolated AH of gender and age differences in the levels of apelin-12 had not been revealed, while they found a correlation level of apelin-12 with SH-groups (r=-0.25, p<0.05), plasma levels of nitrite (r=-0.61, p<0.001). Patients with isolated AH had a high inverse correlation between the level of apelin-12 and the average systolic and diastolic blood pressure, whereas in patients with concomitant GERD and AH and this correlation has been average.
Conclusions. The level of apelin-12 in patients with comorbidity of GERD and AH was significantly higher than in isolated AH and unlike patients with isolated AH and had no correlation with the SH-groups, nitric oxide and have gender differences, inverse correlation with age and more a weak correlation with the mean systolic and diastolic blood pressure.