Background. In our previous work, it was shown that the newly synthesized “onium” hexafluorosilicate has caries preventive effect significantly higher than a similar action of sodium fluoride. This study determined caries-preventive effect of different doses of cetylpyridinium hexafluorosilicate.

Methods. For 35 days rats were obtained Stephan cariogenic diet and different doses (7.5, 15 or 30 mg/kg) of the drug. We determined prevalence caries, activity in the pulp cutters alkaline and acid phosphatases (ALP and ACP, respectively), mineralized index (MI) pulp (ratio ALP/ACP), the content of leukocytes in the blood, leukocyte formula, the activity of serum ALT and ALP, and hemoglobin level in the blood.

Results. The study of drug was provided dose-dependent caries-preventive effect within 31.4–47.1%, increased MI and did not cause significant changes in overall state of the organism. Cetylpyridinium hexafluorosilicate has caries-preventive action and does not have a toxic effect on the body when used as an oral gel at a dose of 30 mg/kg.

Conclusions. Thus, our studies showed a high caries preventive efficacy of cetylpyridinium hexafluorosilicate, depending on the dose in the range of 7.5–30 mg/kg, and in the indicated doses the drug has no toxic effect on the body. Perhaps this is due to the fact that the action of the complex is supplemented with fluoride and antimicrobial lysozyme stimulating effect of cetylpyridinium cation. Furthermore, it should be noted that use of hexafluorosilicate in oral gel composition creates a more effective local concentration of the active ingredients.