ENERGETIC PROFILE IN RATS WITH TRAUMATIC DISEASE OF THE BRAIN AND PHARMACOLOGICAL CORRECTION WITH CORVITINUM

It was experimentally established that in closed craniocerebral trauma in the cells of organs having the aerobic way of metabolism, including red blood cells, there are violations of the tissue respiration, which consist in disorders of oxidation and phosphorylation processes in the respiratory chain of mitochondria, which conditions advantage of energoconsuming processes over energosynthetic processes in the cell.

Introduction of corvitinum predetermines the pronounced protective action concerning energetic reactions of mitochondria under conditions of the examined form of cerebral pathology.

The established facts expose new sides of pharmacodynamics of corvitinum, and should be the reason for wider application of this flavonoid containing drug in clinical practice.