Background. In order to expand the possibilities of using onium hexafluorosilicates as caries-preventive agents we carried out synthesis and studied structure of some properties of biologically active hexafluorosilicates with chlorhexidine, cetylpyridine and guanidine containing cations, which have antibacterial activity. Since the primary task in finding and developing new medicines is the study of the safety of biologically active substances in terms of its single or multiple injection, so the aim of this research was to study the characteristics of cetylpyridinium hexafluorosilicate toxicometry under acute experiment during its oral administration to rats.
Methods. The study of acute toxicity of cetylpyridinium hexafluorosilicate was conducted on 48 Wistar rats weighing 180–220 g for both sexes. The main criterion for quantitative characteristics of cetylpyridinium hexafluorosilicate toxicity was LD50, which was determined using the method of least squares. In addition to comprehensive toxicometry estimation there were calculated the following indicators: 1/LD50 — absolute toxicity, LD84/LD16 — lethal dose range (zone of acute toxic effects), 1/(LD50-S) — the total index of toxicity and S — function of the angle of inclination (lethal doses variability). Extrapolation of toxicometry options per person was carried out using constant biological activity. Statistical analysis of the results was carried out using the program “StatPlus 2009” (the company AnalystSoft, USA, 2009).
Results. The results of cetylpyridinium hexafluorosilicate toxicity under acute experiments show that cetylpyridinium hexafluorosilicate through the oral route of administration is referred to the class III toxicity (moderately toxic compounds). According to variability of lethal doses, cetylpyridinium hexafluorosilicate is referred to compounds having no high potential risk of poisoning and development. The estimated rates of toxicity and hazard of cetylpyridinium hexafluorosilicate show that it does not represent a special hazard to humans. These are relatively low medium lethal dose of absolute toxicity, total toxicity index and high indexes of acute toxic effects zone of cetylpyridinium hexafluorosilicate under the oral route of administration.
Conclusions. Thus, our results prove that cetylpyridinium hexafluorosilicate is a new derivative in the series of “onium” hexafluorosilicates — cetylpyridinium hexafluorosilicate under the oral route of administration is referted to the toxicity class III (moderately toxic compounds).