The investigation of peripheral blood lymphocytes, cytotoxic activity of NK-cells, and level of serum IFNa and IFNg has been carried out in dependence on the amount of the courses of amyxin therapy. Interconnection of immune parameters, interferon status, cytotoxic activity of NK-cells have been analyzed. Dynamics of immunologic parameters and clinical efficacy of chronic hepatitis C patients is compared. It is revealed that long-term amyxin therapy during chronic hepatitis C have positive influence on immune system imbalance and the clinical course of the disease.