PARODONT-PROTECTIVE EFFECT OF QUERCETIN IN RATS WITH HEPATITIS ON THE DYSBIOSIS BACKGROUND

Aim. To determine the role of dysbiosis in the periodontal development at liver pathology and the parodont-protective effect of quercetin.

Materials and methods. In rats there was simulated intestinal dysbiosis using lincomycin and on its background — chronic hepatitis with hydrazine. Quercetin was administered at the dose 4 mg/kg for 20 days. The periodontal condition was evaluated by the levels of inflammation markers in the gums (MDA and protease), the microbial contamination marker (urease), nonspecifc immunity (lysozyme) and antioxidant protection (catalase). In periodontal bone there was determined the activity of alkaline and acid phosphatases, and the protease activity. The degree of dysbiosis by Levitsky was calculated as the ratio of relative activities of urease and lysozyme and the mineralization index was calculated as the ratio of the activities of phosphatases.

Results. The development of dysbiosis in the lining of the small intestine and hepatitis were identified. It was shown a significant increase in the degree of periodontal dysbiosis (10 times), the development of inflammation and the reduction of protective systems. In periodontal bone there was found an increase in proteolysis and the decreased mineralization index. Quercetin administration normalizes the above mentioned indicators.

Conclusion. Hepatitis on the dysbiosis background causes the development of periodontitis. Quercetin has parodont-protective effect.