Background. It is very important to evaluate the influence of the fibrinolytic therapy on the restoration of the endothelial damage markers due to its high prevalence among different methods of treatment.
The aim of research was to estimate the influence of the fibrinolytic therapy on the dynamics of sCD40L and Willebrand factor in patients with acute myocardial infarction and diabetes mellitus type 2.
Materials and methods. 115 patients with acute myocardial infarction were enrolled in this study. They were divided into 2 groups depending on the presence (n=60) or absence (n=55) of diabetes mellitus. Among these, 15 patients with concomitant diabetes mellitus and 25 patients without it were conducted fibrinolysis. Levels of sCD40L and Willebrand factor were measured in the first and tenth days of myocardial infarction by ELISA.
Results and discussion. Presence of the diabetes mellitus in patients with acute myocardial infarction is associated with higher levels of sCD40L ((3.84±0.03) ng/ml) and Willebrand factor ((2.01± ±0.03) U/ml) in comparison with patients without carbohydrate metabolism disturbances ((1.54± ±0.03) U/ml and (3.28±0.06) ng/ml accordingly). By the tenth day levels of these markers decreased in all groups, but the most intense decreasing of Willebrand factor and sCD40L was revealed in patients with concomitant diabetes mellitus after fibrinolysis ((1.59±0.06) U/ml and (2.87±0.14) ng/ml accordingly). It’s confirmed positive influence of the fbrinolytic therapy on the restoration of endothelial function.