Aim. To determine the therapeutic effect of antidysbiotic drugs (ADD) for hepatitis on a dysbiosis background.
Materials and methods. In rats there was reproduced hydrazine hepatitis on the background of lincomycin-induced dysbiosis. Inflammation was assessed by the levels of serum leukocytes, malondialdehyde, protease activity; protective systems were assessed by the lysozyme and catalase activities. The following ADD were tested: biotrit (from wheat germ), extravine (from grapes) and prebiotic inulin (from chicory), which were administered per os for 20 days.
Results. There were found elevated levels of inflammation markers and reduced levels of protection markers. ADD normalized these indicators, but there was a difference in the effectiveness of various ADD on selected indicators of inflammation and protection.
Conclusion. It is advisable to use a complex of ADD in hepatitis on a dysbiosis background.