STUDY OF PHARMACO-TECHNOLOGICAL PROPERTIES OF ALTABOR SUBSTANCE

Introduction. There was derived liquid substance Altabor, which is a complex of ellagic tannins, at theKiev factory “Borshchahivskiy HFZ” from alder cones and adhesive on the original technology. For powdered substance with the purpose of its usage for the development of dosage forms it has been performed contact-drying in the spray liquid extract, a freeze-dryer (without condensing) and in a vacuum oven (via condensation step).

Materials and methods. The article presents the results of study of pharmaco-technological properties of the substance Altabor obtained by various methods of drying. Moisture absorption was determined, the fluidity, angle of repose, bulk density, density after shrinkage compressibility, compactibility substance and ejection force from the tablet matrix.

Results. The results were taken into account when choosing the method of drying the liquid extract to obtain a powdered substance in order to create medicaments on its basis.