On the basis of the conducted experimental researches it is established that 2 % ointment of composition mixture of γ-krotonolaktone and Zn-carnozine derivates has pronounces antiexudative properties and influences the different physiopathological links of inflammatory process in the soft tissues.
The anti-inflammatory mechanism of composition mixture effect is mainly connected with arachidonic acid metabolism influence on the cyclogenesive complex. Due to pronounced antioxidant activity, composition mixture strengthens neutralization of free-radical products of lipid peroxidation of cell membraines, which have special synergism with inflammatory mediators as prostaglandin.
