CHEMISTRY OF 5-METHYLURACILE AND ANTITUMOUR ACTIVITY OF ITS NEW DERIVATIVES

New preparative methods of common anesthetic ftorotan (2-bromo-1,1,1-threefluoro-2-chloroethane) and 1,1-diethylcarboxy-2-chloro-2-threefluoromethylethylene with pharmacaphor groups: =C=CBrCl, –CF2–CHBrCl, –(НО)C=CBrCl, –(CF3)C=C(COOC2H5)2 were described.

A molecular complex of the 5-methyluracile bis-derivative and antitumour bacterial lectine Bacillus polymyxa 102 KGU was obtained.

A strong antitumour effect of 5-methyluracile bis-derivative on the heterotransplantates of human glioma cancer was revealed. A high effect is fixed at the Plissa lymphosarcoma.