A modern man is constantly under the influence of various extreme factors (physical overload, excessive psychoemotional stress, changing the time zone, violation of daily periodicals of sleep, etc.) that leads to mental and physical overloading and induce stress reactions.
This problem is relevant for athletes whose organism undergoes regular physical activity consuming natural resources. Therefore, search for medicines which stimulate physical performance, prevent fatigue and increase adaptive properties of the organism are promising area of medicine and pharmacy. Derivatives of 1,2,4-triazole attract the particular attention among the wide variety of organic heterocyclic compounds. They are characterized by wide spectrum of biological activity and low toxicity.
The aim of our work was pharmacological screening of derivatives of 1,2,4-triazole with actoprotective properties among the synthesized derivatives of 2-((4-amino-5-R1-4H-1,2,4-triazol-3-yl)thio)acetic acids and determination of possible regularities of actoprotective activity from the chemical structure of the compounds.
For studying the actoprotective effect of new derivatives of 1,2,4-triazole, and determine the resistance effect of experimental animals to extreme conditions, the “forced swimming model” was used. In accordance with the methodology the Inosinum (Riboxinum) was used as the reference drug.
As a result of the research there were found four compounds which demonstrated a tendency to actoprotective activity whose results exceeded data of the reference group.
Some regularities of “chemical structure — biological activity” were established, and they can be useful in future synthesis and searching for highly effective actoprotective drugs.