Aim. The aim of our study was determination of the role of of lipid metabolism disorders in the pathogenesis of chronic heart failure in patients with postinfarction cardiosclerosis, type 2 diabetes and obesity.
Materials and methods. There were examined 71 patients with postinfarction cardiosclerosis, type 2 diabetes and obesity, which were divided into four groups. The first group included patients with II functional class of chronic heart failure (n=26), the second — patients with III functional class of chronic heart failure (n=22), the third — patients with IV functional class of chronic heart failure (n=23) and control group consisted of practically healthy people (n=35).
The statistical processing of results was performed with the help of software package “Statistica” (StaSoftInc,USA). The values were calculated: the average (M), dispersion, standard deviation, the median (m), accuracy and level of significance (p). The standard programme of correlation analysis with calculation of average arithmetic means was used: M±m, у, and level of accuracy (p). Pearson correlation coefficient was applied to evaluate the interaction stage between the samples (r).
Results. The level of LDL-C, TG, VLDL, TC and BMI were significantly increased in patients with III FC of chronic heart failure, postinfarction cardiosclerosis, type 2 diabetes and obesity. And level of LDL-C, TG, VLDL, TC and BMI were significantly decreased in patients with IV FC of chronic heart failure, postinfarction cardiosclerosis, type 2 diabetes and obesity. The study showed that in patients with postinfarction cardiosclerosis, type 2 diabetes and obesity the disorders of lipid metabolism were associated with functional class of chronic heart failure.
The role of disorders of lipid metabolism in patients with postinfarction cardiosclerosis, type 2 diabetes and obesity was determined in the pathogenesis of chronic heart failure.