THE STUDY OF ACUTE TOXICITY (LD50) OF THE OINTMENT “TROFEPARIN” FOR TREATMENT OF THROMBOPHLEBITIS

It is studied acute toxicity of the ointment “Trofeparin” according to the method of B. M. Shtabsky on 2 types of animals (the white nonlinear mice of both sexes) of introduction (skin and intragastric). It is established that the ointment “Trofeparin” does not show toxicity with skin and intragastric introduction; with skin application (LD50) the ointment “Trofeparin” exceeds 25,000 mg/kg, but with intragastric introduction is 20,000 mg/kg; the ointment “Trofeparin” belongs to comparatively harmless substances (VI class of toxicity) according to accepted classification.