EPIGENETIC ANALYSIS OF ANAMNESTIC DATA IN REPRODUCTIVE AGE WOMEN WITH UTERINE LEIOMYOMA

Determination of epigenetic risk factors and growth of uterine leiomyoma is of immense practical importance in terms of pathogenesis due to prevention.

Research objective was to make the characteristic epigenetic factors at women of reproductive age to interrelations with leiomyoma of uterus from the point of view of a choice for pathogenetically caused preventive maintenance. There were examined 300 women of reproductive age. The epigenetic risk factors of uterine leiomyoma are following: residence, age of high reproductive activity which is closely connected with the state of hormonal function, the state of chroniostress associated with the social status; uncontrollable intake of drugs and bad habits; unbalanced, irregular, poor-quality food; insufficient motor activity. From the point of view of a choice for pathogenetically caused preventive management of occurrence and progressing uterine leiomyoma, especially of proliferative type, it is necessary to consider the epigenetice factors role in order to decrease their damaging action during prenatal development, puberty, reproductive age.