The aim is to study the changes in the inflammatory markers activity based on determining the dynamics of IL-1β and IL-10 concentrations in patients with various stages of chronic heart failure in the presence of type 2 diabetes and without it.
80 patients (mean age (65.13±8.66) years) with chronic heart failure II–III FC due to ischemic heart disease treated at the Cardiology Department of the Kharkiv Clinical Hospital N 27 were investigated. The first group included 46 patients with chronic heart failure (CHF) diagnosed with type 2 diabetes, the second — 34 CHF patients without type 2 diabetes.
The concentration of the proinflammatory cytokine IL-1β, anti-inflammatory cytokine IL-10 was determined by ELISA.
The presence of type 2 diabetes in patients with CHF and cardiorenal syndrome type 2 is characterized by an imbalance of cytokine system activity, which is manifested by high concentrations of proinflammatory IL-1β and low anti-inflammatory cytokine — IL-10. The attempts of balance work of immunoinflammatory markers are characterized by both pro- and anti-inflammatory link high activity in patients with CHF without type 2 diabetes.