The aim of the study was to examine the association of the KCNJ11 gene polymorphism E23K with the predisposition to the different clinical variants of diabetes mellitus (DM) in Ukrainian population.
Materials and methods. The study was performed in the group of 47 patients with type 1 DM classical clinical form, 83 individuals with LADA (with anti islet, GADA antibodies and low C-peptide levels), 101 patients with type 2 DM and 44 healthy Kharkov inhabitants. The GADA, IA2A and ICA antibodies were measured with RIA. The presence of different variants of the KCNJ11 gene polymorphism was estimated using the DNA sequencing method.
Results. LADA, type 2 and 1 DM patients had the higher E23K polymorphism of KCNJ11 gene frequency, than control data in Kharkov population: the homozygote K/K polymorphism of KCNJ11 gene association with different clinical form of diabetes mellitus was 51.82, 48.51, 48.94% vs 6.82%. Data of our study data suggested powerful association E23K polymorphism of KCNJ11 gene in DM type 2, 1 and LADA patients in comparison to those with health ones: for K/K genotype — ORDM type 1 = 13.10; ORDM type 2 = 12.88; ORLADA = 14.69.
Conclusions. It has been shown, that the homozygote K/K polymorphism of KCNJ11 gene plays the important role in the type 2, 1 and LADA genetic predisposition in Ukrainian population.