Introduction. Although long-term studies of allergic diseases, which are held by the international community of scientists, bronchial asthma is one of the most pressing problems of modern pediatrics.
The arm of the research: to establish parameters of humoral immune system in children of school age for verification severe phenotype of asthma and improve outcomes.
Methods. The study involved 60 school-age children with asthma in remission. Over the course of the disease the patients were divided into two clinical groups. The first (I) clinical group consisted of 30 patients who had been registered severe asthma. The second (II) clinical group formed 30 students with moderately severe asthma.
Results. The average concentration of IL-4 in the serum of children first clinical group was (10.6± ±2.1) mg/ml, and in those of the second clinical group — (7.2±2.5) mg/ml (p>0.05). Concentration of IgM in serum of more than 1 mg/ml was found in 57.7% of patients with severe asthma and in 39.1% of patients in the other clinical groups (p>0.05). The average content of IgA serum of patients with severe asthma reached (1.77±0.15) mg/ml, and the children of the second clinical group — (1.27±0.2) mg/ml (p<0.05).
Conclusions. The relative levels of IgG, greater than 12.0 mg/ml allows verified severe asthma with a sensitivity of 57.7% and a specificity of 81.8%, with odds ratios — 6.1, and personalize treatment policy in these patients. Increased IgA concentration more than 1.8 mg/ml associated with the risk of having severe asthma phenotypes: the absolute risk — 0.5, RR — 2.2 (95% CI 1.2–4.3) with odds ratios — 8.6.