Introduction. The functional estimation of mother-placenta-fetus system represents an important problem in obstetrics. Possibility of many diagnostic methods application in obstetrical practice, for the natural reasons, is limited. The universal indicator of compensatory-adaptive reactions is cardiovascular system which reflects the organism condition regulation mechanisms and adaptive possibilities. A research objective — to study comparative aspects of mother’s, fetus and newborn cardiac rhythm regulation characteristics at physiological pregnancy and placental dysfunction on the basis of the cardiac rhythm variability estimation.
Materials & Methods. 220 pregnant women and their fetuses were under observation (85 — main group with different grades of placental dysfunction and 135 — control group) to perform clinical obstetrical examination, ultrasonic feto- and placentometry, uterine-placental-fetal Doppler, Electrocardiotocography analysis, ELISA for mothers’ and newborns’ hormonal serum levels. We used cardiac rhythm variability, spectral, mathematic and non-parametric analysis for the pregnant, fetus and newborn regulatory and adaptative processes state diagnostics.
Results & Conclusions. The results of the research testify that at physiological pregnancy balance regulation processes of cardiac rhythm was defined in 86.6% of mothers and in 90.4% of fetuses. At placental dysfunction in pregnant women in cardiac rhythm regulation the tension of sympathetic (segmentary) structures in 32.9% (against 11.3%) and/or autonomous — in 49.4% (against 2.3%) was revealed, and at fetus the autonomous regulation influences in 30.6% (against 2.2%) were prevailed, with regulatory and adaptive reactions realization only in the compensated and sub-compensated placental dysfunction phases. The received results are necessary for the diagnostic and forecasting actions’ algorithm workout in women with risk factors.