The endothelial dysfunction has been implicated as a major event in the pathogenesis of essential hypertension (EH). Genetic polymorphism of eNOS gene is associated with endothelial dysfunction development, and therefore with EH.
Aim. To study the influence of polymorphic variants of eNOS gene on the risk of HD development in women.
Materials and methods. In the study 131 patients with EH II stage were enrolled. The control group was composed of 102 women without cardiovascular disease. Polymorphic variants 4a/4b, G894T, T-786C of eNOS gene were studied with the use of PCR and PCR-RFLP methods.
Results. No statistically significant relations were found between eNOS genotypes and EH risk for common group. For women from 18 to 35 years old an increased risk of EH development is determined by the presence of combination of genotypes 4ba/894GG/-786TC of eNOS gene. Women of 36– 54 years old were not found significant differences. Women older than 54 years had increased risk of EH associated with the presence of a combination of genotypes 4bb/-786TT of eNOS gene.
Conclusion. The results suggest that polymorphic variants of eNOS gene, in particular combination of their genotypes, are prognostic markers of EH risk development.