It is known that the efficiency of treatment of numerous diseases, including pulmonary tuberculosis (TB) largely depends on the genetic characteristics of a person, for example from the polymorphism of genes of xenobiotics detoxification. Among them there is an important gene of cytochrome P-450 2E1 (CYP2E1) — an enzyme that participate in metabolism of the most effective antituberculosis drug isoniazid. The aim of present work was to detect the peculiarities of pulmonary tuberculosis (TB) according on cellular content of cells count and biochemical markers in the blood depending on CYP2E1 genotype in Odessa regional antituberculous dispensary in 2012 year.
At the end of in-patient treatment individuals with CC, CD genotype had lower level of hemoglobin and higher amount of leucocytes, and higher level of erythrocyte sedimentation rate. At the beginning as well as at the end of hospital phase treatment patients with CC genotype had higher level of biochemical indices like alanine aminotransferase (AlAT), aspartate aminotransferase (AsAT) and gamma glutathamile transferase than patients with CD, DD genotypes that exhibited higher risk of liver disturbances in СС group. For instance, at the end of in-patient treatment in the individuals with СС genotype the level of AlAT, AsAT was higher by 49.5 % (р<0.001) and 23.9 % (р=0.003) correspondently than in the individuals with СD, DD genotypes. That also correlates with higher concentration of dyene conjugates and lower activity of catalase in patients with CC genotype relatively to patients with CD, DD genotype.