FUNCTIONAL ROLE OF -SH AND -S-S- GROUPS IN DEVELOPMENT OF THE OXIDATIVE STRESS IN CASE OF ACUTE CORONAL SYNDROME

A functional role is studied of -SH and -S-S- groups in development of the oxidative stress in patients with instable angina pectoris (АР), non Q myocardial infarction (MI Q-) and Q myocardial infarction (MI Q+). It has been found that instable АР, MI Q- and MI Q+ are followed by qualitatively new round of disorder in relation between quantity of recovered and oxidized protein and non-ablumin thiogroups. The causes and mechanism of this imbalance, the role of proteins in development of the oxidative modification, peroxidation of proteins and destabilization of lipid-proteinous bonds in LPC have been discussed.