IMUNOHISTOCHEMICAL DESCRIPTION OF DIFFERENTIATION OF HAEMOPOIETIC STEM CELLS OF FETAL LIVER AT DIFFERENT TERMS OF EXPERIMENTAL TRANSPLANTATION

The fetal liver is a unique and insufficiently studied source of pluripotent stem cells. A special interest is caused by factors that influence their directed differentiation in vivo. We conducted the experimental research on rats, which the haemopoietic stem cells of human fetal liver of 6–8 weeks hestation have been transplanted into the ischemic and intact muscular tissue of the hindlimb. The immunohistochemical research (determination of expression of antibodies to the Villebrand factor, to the collagen type IV and vimentine) of processes which take place in the muscular tissue after transplantation of stem cells at different terms of the experiment have been conducted further.