COMPARATIVE EVALUATION OF THERAPEUTIC EFFECT OF COMPOUND DSK-38 AND CITICOLINE UNDER CONDITIONS OF CHRONIC CEREBRAL ISCHEMIA

Considering cerebroprotective properties of sodium salt 4-(2-oxo-3-methyl-2Н-[1,2,4]triazine[2,3-с] quinazolin-6-il) butanoic acid (compound DSK-38) detected in the previous researches it became interesting to investigate influence of this compound on the dynamics of the cognitive and mnestic functions of the neurological status of the rats with acute disorder of the cerebral circulation during a course introduction of the given compound into the rat’s organism.

Experimental model of acute disorder of the cerebral circulation was created by means of ligature of both carotid arteries (CA). Treatment was conducted during 18 days after modeling of ADCC. Compound DSK-38 (10 mg/kg) and citicoline (250 mg/kg) were introduced every day intraperitoneally. Neurological deficiency was determined in the animals by stroke-index C. P. McGrow. Dynamics of orienting-search activity was evaluated in the “open field” test. Evaluation of ability of the animals for studying and remembering of aversive stimulus was investigated in the test of conditioned response of passive avoidance.

Analysis of obtained data demonstrates that treatment course (18 days) of rats with acute disorder of the cerebral circulation with DSK-38 (10 mg/kg) and citicoline (250 mg/kg) results in decreasing of neurological and cognitive deficiency. This was manifested by decreasing of the lethality level and also percentage of animals with severe symptomatic, improvement of orienting-search activity, increasing of percentage of trained animals by conducting test of conditioned response of passive avoidance as compared with a control group (р≤0,05). The important fact that compound DSK-38 didn’t yeild to a reference preparation in these properties. The indicated positive influence of both treatment agents on the neurological and cognitive deficiency course is probably one of the manifestations of the cytoprotective effect. Previous investigations prove it.