On the model of experimental ischemic stroke in rats (by way of irreversible bilateral occlusion of carotid arteries) on the background of correction with Ronkoleukin (0.01 mg/kg) there was noted stabilization of carbohydrate-energetic metabolism (ATP, ADF, AMF and piruvate, lactate, malate) indices, prevention of activation of oxidative modification of protein (AFG, CFG) and the stabilization of apoptosis in neurons of brain cortex.