Fibronectin (FN) and alpha-1-acid glycoprotein (AGP) concentration and rearrangement of leukocyte population on expression of these glycoproteins in erythremia were investigated. Increasing of lymphocyte content that have FN and decreasing of all leukocyte population expressing AGP were revealed. Ratio of cells expressing FN to cells expressing AGP can be used in diagnostics of erythremia.