FIBRONECTIN AND ENDOTHELIAL FUNCTION IN PATIENTS WITH SILICOSIS IN COMBINATION WITH ARTERIAL HYPERTENSION

101 patients (71 persons with silicosis of foundry workers in combination with arterial hypertension (АH), 30 patients with silicosis) aged 54.9±4.87 years, with working experience of 22.7±5.41 years were examined. Endothelial dysfunction was manifested by elevation of ЕТ-1 and was more expressed in patients with combined pathology. Changes of ЕТ-1 and FN was accompanied by ventilation disturbances and, as markers of endothelial dysfunction and inflammatory processes, may be associated with hypoxia and metabolic changes.