CYTOMORPHOLOGIC AND CYTOCHEMICAL CHANGES IN BONE MARROW CELLS EXPOSED FOR XENOGENOUS CEREBROSPINAL FLUID

Xenogenous cerebrospinal fluid is considered a possible base for the production of a powerful therapeutic medicine. Of great importance is the investigation of the bone marrow, as the central organ of haemopoesis and immunogenesis. Morphologic and biochemical changes of bone marrow cells were studied after Romanovsky’s stain, PAS and peroxidase reactions. The study revealed the absence of pathological changes in cells and normal development of progenitor cells. The evident increase of PAS-positive substances, that is glycosamines, was found out in experimental groups, which means the influence of xenogenous cerebrospinal fluid on differentiation process.