MARKERS OF IMMUNE INFLAMMATION AND FUNCTIONAL CLASS OF CHRONIC HEART FAILURE IN ANEMIC PATIENTS WITH CHRONIC KIDNEY DISEASE

Anemia and renal dysfunction are the most frequent comorbidities in patients with chronic heart failure, who have negative impact on prognosis. High activity of cytokines in patients with chronic heart failure has attracted the attention of researchers as an inducer of anemia formation.

The aim of the study is to investigate the changes in activity of markers of immune inflammation based on determining the dynamics of the concentrations of interleukin-6 and interleukin-10 in anemic patients with chronic heart failure of different function class in the presence or absence of chronic kidney disease.

140 anemic patients with II–IV NYHA functional class of chronic heart failure were examined. 71 anemic patients with CHF and CKD were included into the 1st group. The second group consisted of anemic patients with CHF without CKD. The levels of proinflammatory interleukin-6 and antiinflammatory interleukin-10 were estimated by ELISA. The increasing of functional class of chronic heart failure characterized by the increasing of interleukin-6 concentrations regardless of renal dysfunction presence in patients with anemia. The increasing of heart failure severity with renal function depression was accompanied by activation of proinflammatory and exhaustion of antiinflammatory cytokine level, which led to the formation of anemia in patients with chronic heart failure and chronic kidney disease.