Serotoninergic system abnormality usually follows different pathology in organism, a classic example is alcoholic intoxication, which causes increasing of serotonin and tryptophan level.
The goal of this research is the investigation of the serotonin and tryptophan level in rat’s blood serum during chronical alcoholic intoxication including abstinent period.
Materials and methods. The experiment was carried out on white nonlinear rats with weight of 180–200 g that where fed a standard vivarium fodder with free water access. The animals were divided into two parts. The first group consisted of animals, that were intragastric administered distillate water during 10 days. The animals from the second group were administered 30% ethanol. Serotonin and tryptophan level was determined using Ion exchange chromatography and spectroscopy-fluorometric method.
The results of research. Elevation of these metabolites level was shown during a whole period of ethanol introduction including abstinent period, that is the main sign of alcoholic intoxication. These results identify at involving serotoninergic system in forming this pathology. Therefore, deep researches are forward-looking, because information of functioning and abnormality of serotoninergic system is still not complete.