Background. The present study investigated the possible biological activity and pH of 0.001 M aqueous solutions of hexafluorosilicates with six- and five-membered heterocyclic cations of (LH)2SiF6 (L = pyridine and its substituted derivatives, benzimidazole, 2-aminobenzimidazole, 2-amino-5-mercapto-1,3,4-thiadiazole), (LH)2SiF6 × H2O (L = 4-aminopyridine, 2-brom-6-methylpyridine) and (LH2)SiF6 (L = 2,2’-, 4,4’-dipyridyl) for their potential use as caries-preventive agents.
Methods. pH of 0.001 M aqueous solutions of hexafluorosilicates were determined with a universal ionometer EV-74. Assessment of the potential biological activity of heterocyclic bases was performed using the program PASS 11 Professional.
Results. The pH values of 0.001 M aqueous solutions of hexafluorosilicates are independent from the nature of the cation and are in the range 2.95–3.35, which implies that the solutions are in equilibrium with respect to hydrolysis. Analysis of potential biological activities using the program PASS 11 Professional has shown that most of the investigated structures possess a possible sialagogue and immunostimulant activity.
Conclusions. Following the results of this study, hexafluorosilicates with heterocyclic cations could be used as potential caries-preventive agents. The most promising targets for further study may be salts with cations, that have a pronounced antibacterial activity.