The free-radical processes of peroxidation are known to activate in organism of the patient suffering from diabetes mellitus.
The aim of the investigation was to study the state of prooxidant-antioxidant system of small intestine under the condition of type I diabetes and the influence of bioactive substances of bilberry paste on these systems.
Alloxan diabetes in rats was restored with alloxan (100 mg/kg single intra-abdominal taking). Prooxidant system was estimated according to the level of malonic dialdehyde (MDA), antioxidant one — to catalase activity on the 7th and 14th day of experiment. The balance of antioxidant-prooxidant systems was evaluated by API index (ratio of catalase/MDA).
The investigations have shown the considerable growth of the contents of MDA and reduction of catalase activity, and especially, the index of API in mucous membrane of small intestine. The introduction of bilberry paste (4 or 8 g/kg) with food reduces considerably the contents of MDA and normalizes API index (at bilberry dose 8 g/kg)
It was determined that at diabetes mellitus the balance of antioxidant-prooxidant system of mucous membrane of small intestine is disturbed, and it is restored with bioactive substances of bilberry.