An intensive search for effective drugs for the prevention of cognitive deficit caused by acute alcohol intoxication is carried out today. The aim of this work is to study the preventive effectiveness of alkodez on ethanole-induced reduction of training in experimental animals.
To model the severe neurotoxicity of ethanol, animals were injected intraperitoneally ethanol solution (6 g/kg). To study the effect of the compound to training, the first group of animals was injected ethanol 1 hr before training, the second group of animals was injected metadoxin (intraperitoneally at a dose of 200 mg/kg) 1 hr before ethanol administration. To study the consolidation of memory engrams the first group animals were administered ethanol immediately after the training, the second experimental group of animals were injected metadoxin 1 hr before training and ethanol was administered after training.
Animal education and consolidation of memory traces were evaluated by the URPI method in a double-chamber unit of Ugo Bazile production with automatic recording of time spent in the light and dark compartments of the appliance.
Under normal conditions the rate of learning in the control group is good enough. With acute ethanol intoxication it was observed violation of unconditional reflex activity and training animals. The latent period of transition into the dark compartment in animals poisoned with ethanol doubles. Alkodez prevents negative effects of ethanol on animals training.
Alkodez shows some activating effect, which manifests itself in increase the physical activity of animals and increase their vertical supports. However, activation caused by this compound does not affect the formation of a conditioned reflex, on the contrary, it facilitates the formation of an active animal response to the conditioned stimulus.
Ethanol has no effect on the consolidation of memory traces in white rats. In this regard, it is impossible to determine the pharmacological effect of alkodez to consolidate memory engrams in rats poisoned with ethanol.
Thus, alkodez can regulate not only the normal processes of memory, but also act as a corrector in the case of reverse functional impairment with a stress factor.