The antidepressant activity of 2-oxoindoline-3-glycoxylic acid derivatives has been studied on the model of reserpine depression: ethyl ester N-[(2-oxoindoliniliden-3)-2-oxyacetyl] — of the aminoacetyl acid, a leader in the antiamnestic activity (compound 1) and N-[(-2-oxoindoliniliden-3)-2-oxyacetyl]-(1-aminonaphthalene) — a leader in the antidepressive activity (compound 2). The compound 2 shows considerable antidepressant activity, being more active than a classic antidepressant imipramine. The compound 1 doesn’t reveal antidepressive activity on the model of reserpine depression with rats.
