In experiments on albino male rats influence of pyrazinamide toxic doses on lung pool of free amino acids was investigated.
Changes in lung pool of free amino acids indicated possible disturbances in energy metabolism, metabolism of amino acids and other nitrogen containing compounds, processes of gaseous exchange and hemoglobin interaction with oxygen molecules, lipid peroxidation and biomacromolecules methylation.
With 1000 mg/kg of pyrazinamide changes in lung pool of free amino acids were the most expressed. Increasing of pyrazinamide dose up to 2000 mg/kg resulted in weakening of organism’s compensatory possibilities.