In experiments on white rats chronic intoxication was modelled by the way of pesticide 2,4-DA administration during 30 days. With correction of metabolic disorders by the using of antioxidants: a synthetic one — mexidol and combination of natural antioxidants it was found that the drugs inhibit the rate of lipid peroxidation, increase antioxidant activity and providing the body glutathion-dependent enzymes. The data presented indicate the practicability of preparations with antioxidant activity for prevention of metabolic disorders under chronic intoxication with phenoxyacetic acid derivatives.
