N 1 (198) 2026. P. 52–56

COMPLIANCE OF CHILDREN WITH HEMOBLASTOSIS DURING MAINTENANCE THERAPY: AN ANALYSIS OF BARRIERS TО ADHERENCE

M. L. Aryayev, T. R. Kengelyan, L. I. Senkivska

Odesa National Medical University, Odesa, Ukraine

DOI 10.32782/2226-2008-2026-1-8

Background. Treatment adherence is a key factor in the effectiveness of therapy in pediatric hemoblastoses, especially during maintenance therapy.

Objective. To determine the level of compliance with maintenance therapy in children with hemoblastoses and to assess the factors influencing the formation of therapeutic adherence.

Materials and methods. A total of 166 children aged 8–18 years with hemoblastoses were examined; obesity was detected in 66(39.7 %).

Compliance was assessed using clinical and behavioral approaches. Statistical analysis included OR, 95 % CI, and Fisher’s exact test.

Results. Acceptable compliance was established in 84.9 % of children. Risk factors included treatment fatigue, low socioeconomic status, adolescence, and obesity (OR = 3.23).

Conclusions. Compliance has a multifactorial nature, and obesity can be considered an independent predictor of its decrease.

Keywords: children, hemoblastoses, obesity, compliance, maintenance therapy.

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