N 5 (196) 2025. P. 40–45

POSTTHERAPEUTIC ANTIOXIDANT-ASSOCIATED CHANGES IN THE CONCENTRATION OF MARKERS OF INFLAMMATION AND CYTOPROTECTION IN THE BLOOD OF PATIENTS WITH CHRONIC GENERALISED PERIODONTITIS

V. I. Salnykov

Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine

DOI 10.32782/2226-2008-2025-5-6

Despite the successes achieved in the treatment of chronic periodontitis, the problem remains relevant and requires new approaches to drug therapy. In connection with the understanding of the role of oxidative stress in the pathogenesis of periodontitis, the additional inclusion of antioxidants in complex therapy is promising.

The aim of the work: laboratory and biochemical assessment of the effectiveness of complex therapy for chronic generalised periodontitis with the additional inclusion of the antioxidant drug with sodium selenite pentahydrate.

Materials and methods: 60 patients with chronic generalised moderate periodontitis (aged 40 to 65, including 35 women and 25 men) were divided into control and main groups. Patients in the main group were additionally included in complex therapy with the antioxidant sodium selenite pentahydrate.

Results: During the first 10 days (5 times), it was administered by intraoral bivalve transgingival electrophoresis (50 mcg/day), and then at the same dosage “per os” for 20 days. Before the start and after 30 days of treatment, markers of inflammation (IL-1β, TNF-α) and endogenous cytoprotection (HIF-1a and HSP70) were determined in the blood of patients by enzyme-linked immunosorbent assay. Statistical analysis was performed using the software package “STATISTICA® for Windows 6.0” (StatSoft Inc., No. AXXR712D833214FAN5), as well as “SPSS 16.0″ and “Microsoft Excel 2003”. The results obtained demonstrate the promising potential of including sodium selenite pentahydrate in the complex therapy of chronic generalised periodontitis, as an important component of its antioxidant composition.

Keywords: chronic generalised periodontitis, complex therapy, antioxidants, endogenous cytoprotection, inflammation.

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